Abstract #1059

Analysis and visualisation of physiological changes before and after a mild Traumatic Brain injury

Catherine Emata*¹, Eryn Kwon*^2,3, Maryam Tayebi³, Leo Dang^2,4, Adam Donaldson⁵, Vickie Shim³, Allen Champagne⁶, Itamar Terem^7,8, Alan Wang^2,3,4, David Dubowitz ^2,9,10, Sarah-Jane Guild¹¹, Miriam Scadeng ^2,4,10, and Samantha Holdsworth^2,4

¹University of Auckland, Auckland, New Zealand, ²Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, ³Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, ⁴Centre for Brain Research, University of Auckland, Auckland, New Zealand, ⁵Mechatronics Engineering, University of Canterbury, Christchurch, New Zealand, ⁶Centre for Neuroscience Studies, Queen’s University, Kingston, ON, Canada, ⁷Electrical Engineering, Stanford University, Stanford, CA, United States, ⁸Structural Biology, Stanford University, Stanford, CA, United States, ⁹Centre for Advanced MRI, University of Auckland, Auckland, New Zealand, ¹⁰Center for functional MRI, University of California, San Diego, CA, United States, ¹¹Physiology, Faculty of Medical and Health Science, University of Auckland, Auckland, New Zealand

Three advanced sequences were used in conjunction to characterize the physiological changes associated with a mild traumatic brain injury. Amplified Magnetic Resonance Imaging (aMRI) is a motion detection and visualization technique, and is used to amplify pulsatile brain motion. Four-dimensional Flow Magnetic Resonance Imaging (4D flow MRI) is a sequence utilised to analyse and visualise blood flow, while diffusion MRI (dMRI) delineates features of tissue microstructure. Findings included diffusion changes, an increase in blood velocity, and a change in the profile of blood flow to the brain in the carotid arteries, along with increased parenchymal micro-displacements within the brain.

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