Abstract #1066

Altered structural asymmetries of mild white matter injury in preterm infants with different cognitive outcomes

Miaomiao Wang¹, Xianjun Li¹, Congcong Liu¹, Xiaoyu Wang¹, Mengxuan Li¹, Cong Tian¹, Peiyao Chen¹, Chao Jin¹, Xiaocheng Wei², and Jian Yang¹

¹Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi‘an, China, ²MR Research China, GE Healthcare, Beijing, China

Punctate white matter lesions (PWMLs) are common in the preterm. The mild PWMLs may result in cognitive impairments and lesion location is closely associated with neurodevelopmental outcomes. Cognition is a high-order function with multiregional information integration and functional hemispherical lateralization. Therefore, this study aims to investigate the white matter (WM) asymmetries of mild PWMLs in preterm infants with different cognitive outcomes at a corrected age of 6 months by diffusion tensor imaging. Left lateralization of WM development is obviously reduced in mild PWMLs with cognitive delay, while WM asymmetries of PWMLs with normal cognition score are similar with controls.

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