Abstract #1067

GABA and Glu in posterior cingulate cortex of mild TBI patients: MEGA-PRESS and TE averaged PRESS study with spectral averaging

Andrei V. Manzhurtsev^1,2,3, Peter Bulanov³, Maxim Ublinskiy^1,2, Petr E. Menshchikov^2,4, Alexey Yakovlev^1,2, Tolib Akhadov^1,3, and Natalia Semenova^1,2,3,5

¹Radiology, Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, ²Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation, ³Moscow State University, Moscow, Russian Federation, ⁴Philips Healthcare, Russia, Moscow, Russian Federation, ⁵Semenov Institute of Chemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation

In this study, GABA and Glu are measured in the posterior cingulate cortex (PCC) of children with acute mTBI using MEGA-PRESS and TE averaged PRESS. Spectra were processed individually and after between-subject group averaging. The results demonstrate the increase in Glu without glutamine contribution and the stability of GABA without macromolecule contamination which means that the excitatory-inhibitory neurotransmitter balance is shifted towards excitation in the cerebral region studied. Spectral averaging over groups of participants recommends itself as a powerful tool, if used with proper preprocessing steps.

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