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Abstract #1073

Comparison of Gadolinium- and Iron-Oxide-based Perfusion Imaging Metrics in Glioblastoma

Ashley M. Stokes1, Sudarshan Ragunathan1, Laura Bell1, Ekokobe Fonkem2, John Karis3, and C. Chad Quarles1
1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Neuro-Oncology, Barrow Neurological Institute, Phoenix, AZ, United States, 3Neuroradiology, Barrow Neurological Institute, Phoenix, AZ, United States

Relative cerebral blood volume (rCBV) maps are adversely impacted by contrast agent leakage effects when acquired using gadolinium-based contrast agents, and these effects can be corrected using standard leakage correction methods. In a cohort of high-grade glioma patients, we compared leakage-corrected rCBV maps acquired using gadolinium-based contrast agents to rCBV acquired using an intravascular iron-oxide-based contrast agent. The rCBV maps from both contrast agents were similar, with high voxel-wise agreement, suggesting that leakage effects are appropriately removed from rCBV maps using standard leakage correction methods.

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