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Abstract #1074

Do You Double-Dose? Clinical Validation of Single-Dose, Dual-Echo Perfusion Protocols in Glioma Patients

Ashley M. Stokes1, Taylor Olvey1, Leland S. Hu2, Leslie C. Baxter2, Laura C. Bell1, C. Chad Quarles1, and Lea Alhilali3
1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Mayo Clinic Arizona, Phoenix, AZ, United States, 3Neuroradiology, Barrow Neurological Institute, Phoenix, AZ, United States

Relative cerebral blood volume (rCBV) obtained from dynamic susceptibility contrast (DSC) MRI is adversely impacted by contrast agent leakage effects in enhancing brain tumors, often necessitating multiple contrast doses. The purpose of this study is to compare dual-echo rCBV maps (single-dose) with standard rCBV maps (double-dose) in patients with high-grade gliomas using commercially available software. High agreement was observed between rCBV maps with single- and double-doses, with substantial flexibility across pulse sequence parameters. This protocol could be used to lower costs and contrast dose in clinical settings, as well as eliminate variability in perfusion methods related to contrast timing schemes.

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