Abstract #1087

The use of a DSC-MRI perfusion atlas for cerebral blood volume normalization and its impact in improving prognostic estimation.

Elies Fuster-Garcia¹, Javier Juan Albarracín², Ivar T Hovden³, Maria del Mar Ávarez-Torres², Alex Rovira⁴, Laura Oleaga⁵, Antonio J. Revert⁶, Silvano Filice⁷, Juan Miguel García-Gómez², and Kyrre Eeg Emblem⁸

¹Diagnostic Phyisics, Oslo University Hospital, Oslo, Norway, ²Universitat Politècnica de València, València, Spain, ³Oslo University Hospital, Olso, Norway, ⁴Hospital Universitari Vall d'Hebron, Barcelona, Spain, ⁵Hospital Clínic, Barcelona, Spain, ⁶Hospital de Manises, Manises, Spain, ⁷Azienda Ospedaliero-Universitaria di Parma, Parma, Italy, ⁸Diagnostic Physics, Oslo University Hospital, Oslo, Norway

In this work we present a method to improve the normalization of CBV maps by using a CBV atlas of the brain. This CBV atlas was generated using 134 non-linearly registered CBV maps from NCT03439332 clinical study. The proposed normalization method generates CBV values that better correlate with the patients’ OS, reaching smaller more significant p-values (p=0.034) based on Cox regression analysis, that better differentiate between high and low survivors (AUC=0.60, p=0.007) based on Kaplan Meier analysis.

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