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Abstract #1087

The use of a DSC-MRI perfusion atlas for cerebral blood volume normalization and its impact in improving prognostic estimation.

Elies Fuster-Garcia1, Javier Juan Albarracín2, Ivar T Hovden3, Maria del Mar Ávarez-Torres2, Alex Rovira4, Laura Oleaga5, Antonio J. Revert6, Silvano Filice7, Juan Miguel García-Gómez2, and Kyrre Eeg Emblem8
1Diagnostic Phyisics, Oslo University Hospital, Oslo, Norway, 2Universitat Politècnica de València, València, Spain, 3Oslo University Hospital, Olso, Norway, 4Hospital Universitari Vall d'Hebron, Barcelona, Spain, 5Hospital Clínic, Barcelona, Spain, 6Hospital de Manises, Manises, Spain, 7Azienda Ospedaliero-Universitaria di Parma, Parma, Italy, 8Diagnostic Physics, Oslo University Hospital, Oslo, Norway

In this work we present a method to improve the normalization of CBV maps by using a CBV atlas of the brain. This CBV atlas was generated using 134 non-linearly registered CBV maps from NCT03439332 clinical study. The proposed normalization method generates CBV values that better correlate with the patients’ OS, reaching smaller more significant p-values (p=0.034) based on Cox regression analysis, that better differentiate between high and low survivors (AUC=0.60, p=0.007) based on Kaplan Meier analysis.

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