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Abstract #1086

Short-term reproducibility of cerebral metabolism using magnetic resonance imaging

Ulrich Lindberg1, Signe Sloth Madsen2, Karsten Skovgaard Olsen2, Kirsten Møller2,3, Mohammad Sohail Asghar2, Henrik Bo Wiberg Larsson1,3, and Mark Bitsch Vestergaard1
1Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark, 2Department of Neuroanaesthesiology, Rigshospitalet, Copenhagen, Denmark, 3Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

The aim of this study was to investigate the short-term physiological variation in global cerebral perfusion, oxygen consumption and metabolite concentration, measured by MRI. Global cerebral oxygen consumption as well as N-acetyl-aspartate concentration remain stable over a one-week period. Global cerebral perfusion and lactate concentration was correlated, though showed decreasing within-subject correlation with increasing delay between scan session during the one-week follow-up period. These results should be carefully considered when performing longitudinal studies. In conclusion MRI does provide robust reliable measurements of global cerebral metabolism.

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