Abstract #1085

High resolution BBB water exchange rate mapping with multi-delay diffusion prepared pseudo-continuous arterial spin labeling

Xingfeng Shao¹ and Danny JJ Wang^1,2

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Neurology, University of Southern California, Los Angeles, CA, United States

A segmented 3D diffusion prepared pseudo-continuous arterial spin labeling (DP-pCASL) sequence is proposed to acquire high resolution whole brain map of water exchange rate (kw) across the blood-brain barrier. And a new acquisition protocol is proposed which acquires DP-pCASL signals at multiple long post-labeling delays (PLDs) and allows kw to be quantified with a robust regression step and without the need for signal division or additional physiological parameter as inputs.

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