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Abstract #1085

High resolution BBB water exchange rate mapping with multi-delay diffusion prepared pseudo-continuous arterial spin labeling

Xingfeng Shao1 and Danny JJ Wang1,2
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Neurology, University of Southern California, Los Angeles, CA, United States

A segmented 3D diffusion prepared pseudo-continuous arterial spin labeling (DP-pCASL) sequence is proposed to acquire high resolution whole brain map of water exchange rate (kw) across the blood-brain barrier. And a new acquisition protocol is proposed which acquires DP-pCASL signals at multiple long post-labeling delays (PLDs) and allows kw to be quantified with a robust regression step and without the need for signal division or additional physiological parameter as inputs.

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