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Abstract #1084

Comparing Preservation of Ex-Vivo Lungs for Transplantation, Using 31P MRS: Extended Ex-Vivo Lung Perfusion and Cold Static Storage

Jonathan Snow1, Mehrdad Pourfathi1, Ian Duncan1, Harrilla Profka1, Stephen Kadlecek1, Yi Xin1, Mostafa Ismail1, Sarmad Siddiqui1, Luis Loza1, Tahmina Achekzai1, Xiaoling Jin1, Hooman Hamedani1, Faraz Amzajerdian1, Federico Sertic1, Kai Ruppert1, Ryan Baron1, Gabriel Unger1, Maurizio Cereda1, Shampa Chatterjee1, and Rahim Rizi1
1University of Pennsylvania, Philadelphia, PA, United States

Due to a shortage of transplantable lungs, careful preservation of viable donor lungs is of paramount importance. Ex-Vivo Lung Perfusion (EVLP) and cold static storage are two clinical techniques used to preserve donor lungs prior to transplantation. In this study, magnetic resonance spectroscopy was used to compare the ability of un-ventilated normothermic EVLP vs. cold static storage to preserve rat lungs’ ATP energy status over a 5-hour ischemic period. The EVLP model was slightly better than cold static storage at sustaining the lungs’ ATP.

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