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Abstract #1083

Evaluating the Effects of Motion Compensation to IVIM Fitting in In-Vivo DW-MRI of the Muscle

Jaume Coll-Font1,2,3, Or Perlman2,3, Shi Chen1, Robert A Eder1, Christian T. Farrar2,3, and Christopher T. Nguyen1,2,3
1Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Charlestown, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 3Harvard Medical School, Boston, MA, United States

In order to acquire diffusion-weighted images (DWI) of the heart, motion compensated (M2) techniques are needed. However, these reduce the sensitivity to perfusion (D*) and hence hamper the accurate estimation of IVIM parameters. Here, we evaluate the effects of M2 to the IVIM estimates in the lower leg muscle and assess feasibility of an approach to combine DWI acquired with and without M2 to fit IVIM models. Our results show that M2 underestimates D* in the IVIM model. On the other hand, the combined approach resulted in IVIM parameter estimates similar to those obtained with standard DW MR.

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