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Abstract #1082

Characterization of Microcirculatory Regulation in Skeletal Muscle using Wavelet Coherence Analysis of Resting-State BOLD MRI

Jingting Yao1, Benjamin Risk1, Marijn Brummer1, Adam Daniel Singer1, Jeanie Park1, and David Reiter1
1Emory University, Atlanta, GA, United States

Microcirculatory regulation in the musculoskeletal system ensures tissue oxygenation and nutrient supply that are essential for maintaining normal muscular functions. BOLD MRI-derived mapping indices M0 and T2* have previously been established as markers of blood volume and blood oxygenation in healthy subjects. This study assesses dynamic resting-state microcirculation in the calf of healthy subjects using the wavelet coherence analysis, a time-frequency approach. Quantitative wavelet-based metrics characterizing the dynamic relationship between M0 and T2* may serve as markers of blood perfusion control and useful for characterizing degraded peripheral microvascular control in diseased population.

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