Microcirculatory regulation in the musculoskeletal system ensures tissue oxygenation and nutrient supply that are essential for maintaining normal muscular functions. BOLD MRI-derived mapping indices M0 and T2* have previously been established as markers of blood volume and blood oxygenation in healthy subjects. This study assesses dynamic resting-state microcirculation in the calf of healthy subjects using the wavelet coherence analysis, a time-frequency approach. Quantitative wavelet-based metrics characterizing the dynamic relationship between M0 and T2* may serve as markers of blood perfusion control and useful for characterizing degraded peripheral microvascular control in diseased population.
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