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Abstract #1081

Evaluation of Brain Glioma Using Non-Contrast Cerebral Blood Volume Mapping: Correlations between Vascular proliferation and Perfusion MR

Yaoming Qu1, Qin Qin1,2, Haitao Wen1, Xiaochan Ou1, Yingjie Mei3, Weibo Chen4, and Zhibo Wen1
1Radiology, Zhujiang hospital of southern medical university, Guangzhou, China, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Philips Healthcare, Guangzhou, China, 4Philips Healthcare, Shanghai, China

Cerebral blood volume (CBV) mapping employing velocity-selective saturation pulse trains is an emerging velocity-selective arterial spin labeling (VSASL) based method for quantifying perfusion with higher SNR. Its utility was assessed for glioma patients at 3T and corelation between histopathologic vascular proliferation and perfusion MR Imaging. VSASL based CBV mapping, in good agreement with DSC-PWI and VSASL based cerebral blood flow (CBF) mapping, showed great promise for accurate quantitative assessment and preoperative grading of brain gliomas, and further potential in the IDH genotype and vascular proliferation status predicting.

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