Abstract #1080

Simultaneous Effects of tDCS on Cerebral Blood Flow and Metabolic Response in Healthy Controls

Marco Muccio, MSc¹, Lillian Walton Masters¹, Giuseppina Pilloni, PhD¹, Lauren Krupp, MD¹, Abhishek Datta, PhD², Marom Bikson, PhD³, Leigh Charvet, PhD¹, and Yulin Ge, MD¹

¹Department of Radiology, NYU Grossman School of Medicine, New York City, NY, United States, ²Soterix Medical Inc., New York City, NY, United States, ³Department of Biomedical Engineering, City College of New York, New York City, NY, United States

The underlying biological mechanisms of transcranial direct current stimulation (tDCS) remain relatively uncharacterized. In this report, MRI measures for cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) of healthy controls was acquired before and during tDCS to better understand real-time neuronal response. We observed a significant increase in global CBF suggesting an increase of neuronal activity during compared to before tDCS. CMRO2 showed an increase of ~7% during tDCS compared to before tDCS. We suggest that the reported cortical excitability increase may also serve as a potential biomarker for neuronal reactivity or plasticity in many neurodegenerative diseases.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.