Meeting Banner
Abstract #1080

Simultaneous Effects of tDCS on Cerebral Blood Flow and Metabolic Response in Healthy Controls

Marco Muccio, MSc1, Lillian Walton Masters1, Giuseppina Pilloni, PhD1, Lauren Krupp, MD1, Abhishek Datta, PhD2, Marom Bikson, PhD3, Leigh Charvet, PhD1, and Yulin Ge, MD1
1Department of Radiology, NYU Grossman School of Medicine, New York City, NY, United States, 2Soterix Medical Inc., New York City, NY, United States, 3Department of Biomedical Engineering, City College of New York, New York City, NY, United States

The underlying biological mechanisms of transcranial direct current stimulation (tDCS) remain relatively uncharacterized. In this report, MRI measures for cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) of healthy controls was acquired before and during tDCS to better understand real-time neuronal response. We observed a significant increase in global CBF suggesting an increase of neuronal activity during compared to before tDCS. CMRO2 showed an increase of ~7% during tDCS compared to before tDCS. We suggest that the reported cortical excitability increase may also serve as a potential biomarker for neuronal reactivity or plasticity in many neurodegenerative diseases.

This abstract and the presentation materials are available to members only; a login is required.

Join Here