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Abstract #1079

Aberrant cerebral perfusion pattern in amnestic mild cognitive impairment and Parkinson’s disease with mild cognitive impairment

Song'an Shang1, Weiqiang Dou2, and Jingtao Wu3
1Nanjing First Hospital, Nanjing Medical University, Nanjing, China, 2GE Healthcare, MR Research China, Beijing, China, 3Northern Jiangsu People’s Hospital, Yangzhou, China

We investigated the aberrations in regional perfusion properties among amnestic mild cognitive impairment (aMCI) patients, patients with Parkinson’s disease with MCI (PD-MCI), and healthy control (HC) by using 3D arterial spin labeling (ASL) imaging. Our results showed that normalized cerebral blood flow (CBF) as measured by 3D ASL revealed different patterns of perfusion between aMCI and PD-MCI, probably linked to distinct neural mechanisms. Therefore, this preliminary study demonstrates that normalized CBF might provide specific perfusion information for further pathological and neuropsychological studies.

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