Abstract #1078

The relative cerebral blood volume in normal-appearing white and grey matter remains almost constant following radio(chemo)therapy

Katharina Witzmann^1,2, Felix Raschke^1,2, Tim Wesemann³, Mechthild Krause^1,2,4,5,6, Jennifer Linn³, and Esther G.C. Troost^1,2,4,5,6

¹Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology – OncoRay, Dresden, Germany, ²OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ³Institute of Neuroradiology, University Hospital Carl Gustav Carus and Medical Faculty of Technische Universität Dresden, Dresden, Germany, ⁴Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, ⁵National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and; Helmholtz Association / Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany, ⁶German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany

In adjuvant radio(chemo)therapy of glioma patients, irradiation of tumor-surrounding normal tissue is unavoidable, potentially leading to long-term side-effects. We analyzed radiation-induced perfusion changes measured as relative cerebral blood volume (rCBV) in supraventricular grey and white matter regions of 17 glioma patients before and 3, 6 and 9 months after radiotherapy. After treatment, perfusion remained constant in the entire regions and after dose-separation, except for a statistically significant rCBV decrease in low-dose white matter volumes 6 months after the end of radiotherapy (p=0.008) and a trend towards increasing white and grey matter perfusion in high-dose volumes at 9 months (p<0.1).

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