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Abstract #1123

Influence of gadolinium-based contrast agent on DWI and ADC values in breast lesions

Kay van der Hoogt1, Robert-Jan Schipper1, Ronni Wessels1, Cees de Graaf1, Arjan te Boekhorst1, Leon ter Beek2, Regina Beets-Tan1, and Ritse Mann1
1Radiology, the Netherlands Cancer Institute – Antoni van Leeuwenhoek, Amsterdam, Netherlands, 2Medical Physics, the Netherlands Cancer Institute – Antoni van Leeuwenhoek, Amsterdam, Netherlands

It is advocated to perform breast DWI-acquisitions before contrast administration [1]. However, performing DWI after contrast MRI might be more practical in a clinical context. Several studies [2] evaluated whether performing breast MRI before or after contrast administration impacts the DWI classifying properties. However, previous research was often based on an interpatient analysis. Therefore, we performed a retrospective intra-patient analysis on perfusion-free ADC-maps before and after contrast administration. A decrease in ADC was observed in post-contrast ADC-values. This was independent of the B0-field strength, and similar for benign and malignant lesions.

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