This study aims to analyze the value of ADC, IVIM and DKI in differentiating benign and malignant breast nodules. The combination of all the quantitative diffusion parameters is also evaluated. The value of ADC, IVIM-D, KDI-K and DKI-D can be used as a diagnostic tool for evaluating benign and malignant breast lesions. Compared with IVIM-D, DKI-K and DKI-D, ADC value is the best single discriminative parameters to differentiate breast lesions. Further, the combination of ADC and DKI-K value shows the best diagnostic efficacy.