The aim of our study was to investigate the early predictive value of IVIM-DWI in neoadjuvant chemotherapy for breast cancer. 43 cases of breast cancer confirmed by pathological puncture biopsy in our hospital were enrolled in this study. Four courses of neoadjuvant chemotherapy were used to evaluate the efficacy. The conclusion obtained via the present study is IVIM-DWI can predict the early curative effect of neoadjuvant chemotherapy for breast cancer and evaluate its effectiveness. It can assist conventional MRI to evaluate the curative effect.