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Abstract #1136

Increased Saturated Fatty Acid Fraction in the Adipose Tissue Near Malignant Tumors in Breast Cancer Patients

Mehran Baboli1, Pippa Storey2, Terlika Pandit Sood2, Justin Fogarty2, Melanie Moccaldi2, Alana Lewin2, Linda Moy2, and Sungheon Gene Kim1
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Radiology, NYU Langone Health, New York, NY, United States

We assessed the distribution of saturated fatty acid (SFA) in the adipose tissue around malignant tumors and the whole breast of patients with benign and malignant lesions. Bilateral gradient echo spectroscopic imaging sequence was acquired simultaneously. A voxel-wise analysis in the frequency domain was then applied to measure the SFA in each breast's adipose tissues and peri-tumoral region. Our results showed that the SFA was significantly higher around the malignant tumor than on the contralateral side, while no significant changes were observed with benign lesions. The results indicate that the SFA may be closely associated with the malignancy of lesions.

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