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Abstract #1141

The Performance of Breast Diffusion Tensor Imaging in the Evaluation of Pre-Surgical Treatment of Breast Cancer.

Anabel M Scaranelo1, Edna Furman-Haran2, Abdullah Alabousi3, Dov Grobgeld2, Vivianne Freitas1, and Hadassa Degani4
1Medical Imaging, University of Toronto, Toronto, ON, Canada, 2Weizmann Institute of Science, Rehovot, Israel, 3Department of Radiology, St Joseph's Healthcare. McMaster University, Hamilton, ON, Canada, 4DDE MRI Solutions Ltd., Tel Aviv, Israel

Response to breast neoadjuvant systemic therapy (NAST) was longitudinaly monitored with Diffustion Tensor Imaging (DTI) pre and post therapy and evaluated in reference to post surgery histopatholgy results. A correlation was demonstrated between DTI residual tumor size and pathology size. Response in the various breast cancer subtypes was revealed by increased λ 1 values validated by a correlation with the pathological residual disease. DTI detected pCR in all breast subtypes with a good sensitivity and specificity

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