Abstract #1141

The Performance of Breast Diffusion Tensor Imaging in the Evaluation of Pre-Surgical Treatment of Breast Cancer.

Anabel M Scaranelo¹, Edna Furman-Haran², Abdullah Alabousi³, Dov Grobgeld², Vivianne Freitas¹, and Hadassa Degani⁴

¹Medical Imaging, University of Toronto, Toronto, ON, Canada, ²Weizmann Institute of Science, Rehovot, Israel, ³Department of Radiology, St Joseph's Healthcare. McMaster University, Hamilton, ON, Canada, ⁴DDE MRI Solutions Ltd., Tel Aviv, Israel

Response to breast neoadjuvant systemic therapy (NAST) was longitudinaly monitored with Diffustion Tensor Imaging (DTI) pre and post therapy and evaluated in reference to post surgery histopatholgy results. A correlation was demonstrated between DTI residual tumor size and pathology size. Response in the various breast cancer subtypes was revealed by increased λ 1 values validated by a correlation with the pathological residual disease. DTI detected pCR in all breast subtypes with a good sensitivity and specificity

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