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Abstract #1148

Intra-tumoural lipid composition and lymphovascular invasion in breast cancer via non-invasive magnetic resonance spectroscopy

Sai Man Cheung1, Ehab Husain2,3, Vasiliki Mallikourti1, Yazan Masannat3,4, Steven D Heys4, and Jiabao He1
1Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom, 2Pathology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 3School of Medicine, University of Aberdeen, Aberdeen, United Kingdom, 4Breast Unit, Aberdeen Royal Infirmary, Aberdeen, United Kingdom

Lymphovascular invasion (LVI) is associated with increased recurrence and metastatic risk in breast cancer. LVI, with genetic mutation in metabolism of saturated and monounsaturated fatty acids, leads to the deregulation of lipid composition. Currently LVI is estimated using the pre-operative core biopsy, while definitive LVI can only be determined after surgery, precluding patients to receive timely neoadjuvant chemotherapy or hormonal treatment. Double quantum filtered correlation spectroscopy (DQF-COSY) is a method capable of accurate non-­invasive lipid composition quantification. We therefore hypothesised there is a difference in lipid composition derived from DQF-COSY between LVI status.

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