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Abstract #1147

Triple negative breast cancer COX-2 expression distinctly alters spleen metabolism in immunocompromised mice compared to immunocompetent mice

James Dion Barnett1, Marie-France Penet1, Balaji Krishnamachary 1, Zaver Bhujwalla1, Flonne Wildes1, Santosh Kumar Bharti1, and Yelena Mironchik1
1The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Cycloxygenase-2 (COX-2) is a pathological marker of high clinical relevance. COX-2 initiates the biosynthesis of inflammatory and immunosuppressive prostanoids to promote a hostile tumor microenvironment. Solid tumors rely on vital organs such as the spleen to survive, proliferate and evade immune recognition. We modulated breast cancer COX-2 expression to investigate the metabolic effects in the spleen of immunocompetent and immunocompromised mice. High resolution 1H magnetic resonance spectroscopy (MRS) was performed to identify changes in spleen metabolites. We observed distinct, COX-2-dependent increases in various metabolites in severe combined immunodeficient (SCID) mice compared to immunocompetent BALB/c mice.

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