Cycloxygenase-2 (COX-2) is a pathological marker of high clinical relevance. COX-2 initiates the biosynthesis of inflammatory and immunosuppressive prostanoids to promote a hostile tumor microenvironment. Solid tumors rely on vital organs such as the spleen to survive, proliferate and evade immune recognition. We modulated breast cancer COX-2 expression to investigate the metabolic effects in the spleen of immunocompetent and immunocompromised mice. High resolution 1H magnetic resonance spectroscopy (MRS) was performed to identify changes in spleen metabolites. We observed distinct, COX-2-dependent increases in various metabolites in severe combined immunodeficient (SCID) mice compared to immunocompetent BALB/c mice.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords