Abstract #1146

Impact of low-rank denoising on abbreviated breast diffusion-weighted acquisitions: accuracy and repeatability

Patrick J Bolan¹, Jessica A McKay², Mehmet Akcakaya³, An L Church⁴, Michael T Nelson⁴, Kamil Ugurbil¹, and Steen Moeller¹

¹Radiology / Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ²Radiology, Stanford University, Palo Alto, CA, United States, ³Electrical and Computer Engineering /CMRR, University of Minnesota, Minneapolis, MN, United States, ⁴Radiology, University of Minnesota, Minneapolis, MN, United States

This study explores the use of a low-rank denoising technique (NORDIC) on breast DWI. Accuracy and repeatability were assessed by subdividing full acquisitions into shorter scans, calculating ADC with and without NORDIC, and comparing the resultant ADC maps. We found that the denoising effects were dependent on SNR – low SNR regions (e.g., background) had greater denoising efficacy than high SNR regions. These findings indicate that NORDIC may help improve assessment of small lesions, and could be used to prospectively optimize higher-resolution acquisition protocols.

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