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Abstract #1145

High spatial and temporal resolution breast DCE-MRI using MOCCO reconstruction for quantitative PK analysis

Ping N Wang1, Julia V Velikina2, Leah C Henze Bancroft2, Alexey A Samsonov2, Frederick Felcz2, Roberta M Strigel1,2,3, and James H Holmes2
1Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United States

Radial acquisition with MOCCO reconstruction has been proposed for high spatial and temporal resolution breast DCE imaging. However, the performance of the method has not been evaluated across a wide range of temporal enhancement curves. In this work, we use a breast digital reference object with the ability to provide a wide range of lesion contrast kinetics using the extended Tofts model for pharmacokinetic simulation. A voxel-by-voxel quantitative analysis was applied and compared with the ground truth.

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