Abstract #1145

High spatial and temporal resolution breast DCE-MRI using MOCCO reconstruction for quantitative PK analysis

Ping N Wang¹, Julia V Velikina², Leah C Henze Bancroft², Alexey A Samsonov², Frederick Felcz², Roberta M Strigel^1,2,3, and James H Holmes²

¹Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United States

Radial acquisition with MOCCO reconstruction has been proposed for high spatial and temporal resolution breast DCE imaging. However, the performance of the method has not been evaluated across a wide range of temporal enhancement curves. In this work, we use a breast digital reference object with the ability to provide a wide range of lesion contrast kinetics using the extended Tofts model for pharmacokinetic simulation. A voxel-by-voxel quantitative analysis was applied and compared with the ground truth.

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