Abstract #1192

Microfluidic preparation of liposomal hydrogel microbeads containing CT agents (CT-lipobeads) to longitudinally monitor pH using CEST MRI

Peng Xiao¹, Jianpan Huang¹, Xiongqi Han¹, Jacinth Wing-Sum Cheu², Joseph Lai¹, Lok Hin Law¹, Carmen Chak-Lui Wong^2,3, and Kannie Wai Yan Chan^1,4,5

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, ²Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, ³State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, Hong Kong, ⁴City University of Hong Kong Shenzhen Research Institute, Shen Zhen, China, ⁵Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Iodinated CT contrast agents(CA) had been investigated as CEST contrast agent while high dose of CA and quick clearance could limit their potential for monitoring pH longitudinally. Here, we aim to introduce CT-lipobeads to address this issue. The CT-lipobeads showed 10% CEST contrast and good pH dependency at pH 6.0-7.0, which is sensitive to distinguish hypoxic medium from normoxic medium. Moreover, CT-lipobeads generated CEST contrast of 9% in the subcutaneous compartment, and contrast remained constant over a week. These findings demonstrated a robust approach for fabrication of CT-lipobeads with decent CEST contrast for longitudinal pH imaging.

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