Abstract #1195

The sensitivity of amide, amine, creatine and guanidinium CEST in detecting pH at high MRI field

Lin Chen^1,2 and Jiadi Xu^1,2

¹Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

We compared the sensitivity of several chemical exchange saturation transfer (CEST) contrasts in detecting altered pH at 11.7 T MRI. Studies with egg white phantom revealed that amide and guanidium CEST contrasts in protein are suitable for pH mapping at the physiological relevant range (6.5-7.5), while amineCEST works well for pH lower than 6.5. Hypercapnia (20%) study in mouse brain indicated that creatineCEST showed both higher pH sensitivity and signal intensity compared with amide and guanidium CEST at the physiological pH range and is more suitable for in vivo pH studies at high field.

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