We compared the sensitivity of several chemical exchange saturation transfer (CEST) contrasts in detecting altered pH at 11.7 T MRI. Studies with egg white phantom revealed that amide and guanidium CEST contrasts in protein are suitable for pH mapping at the physiological relevant range (6.5-7.5), while amineCEST works well for pH lower than 6.5. Hypercapnia (20%) study in mouse brain indicated that creatineCEST showed both higher pH sensitivity and signal intensity compared with amide and guanidium CEST at the physiological pH range and is more suitable for in vivo pH studies at high field.
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