Abstract #1196

Novel phosphorous-based polymer for 31P-magnetic resonance imaging

Natalia Ziółkowska^1,2, Ladislav Androvič³, Lucie Woldřichová³, Martin Vít^1,4, David Červený^1,5, Olga Šebestová Janoušková³, Richard Laga³, and Daniel Jirák^1,2

¹Site of Computed Tomography, Magnetic Resonance Imaging, and Clinical and Experimental Spectroscopy, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Prague, Czech Republic, ³Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic, ⁴Faculty of Mechatronics Informatics and Interdisciplinary Studies, Technical University of Liberec, Liberec, Czech Republic, ⁵Faculty of Health Studies, Technical University of Liberec, Prague, Czech Republic

Our work is focused on the development and investigation of novel polymer-based contrast agent for ³¹P magnetic resonance (³¹P MR). The proposed diagnostics is a methacrylate-type polymer containing a phosphorothioate group (p(TMPC)), which causes a significant chemical shift of phosphorus, making it easily distinguishable from other biological phosphorus components, and is thus easily traceable by ³¹P MRI. Results from ³¹P MR imaging, spectroscopy and relaxometry obtained at 4.7T show very good MR properties, thus p(TMPC) represent a very promising diagnostic tool for in vivo use.

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