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Abstract #1196

Novel phosphorous-based polymer for 31P-magnetic resonance imaging

Natalia Ziółkowska1,2, Ladislav Androvič3, Lucie Woldřichová3, Martin Vít1,4, David Červený1,5, Olga Šebestová Janoušková3, Richard Laga3, and Daniel Jirák1,2
1Site of Computed Tomography, Magnetic Resonance Imaging, and Clinical and Experimental Spectroscopy, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Prague, Czech Republic, 3Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic, 4Faculty of Mechatronics Informatics and Interdisciplinary Studies, Technical University of Liberec, Liberec, Czech Republic, 5Faculty of Health Studies, Technical University of Liberec, Prague, Czech Republic

Our work is focused on the development and investigation of novel polymer-based contrast agent for 31P magnetic resonance (31P MR). The proposed diagnostics is a methacrylate-type polymer containing a phosphorothioate group (p(TMPC)), which causes a significant chemical shift of phosphorus, making it easily distinguishable from other biological phosphorus components, and is thus easily traceable by 31P MRI. Results from 31P MR imaging, spectroscopy and relaxometry obtained at 4.7T show very good MR properties, thus p(TMPC) represent a very promising diagnostic tool for in vivo use.

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