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Abstract #1197

PAA-g-(DTPA-Gadolinium): A Versatile Agent to Visualize the Effiencient Interstitial Stream at 7 Tesla

Xiaohan Zhou1,2, Yi Hou3, Wentao Liu1, and Dong Han1,2
1National Centre for Nanoscience and Technology, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Beijing University Of Chemical Technology, Beijing, China

Interstitium space and interstitial stream compartmentalize organs distributed in different regions and compose human body among parenchymal tissues. The increase in interests to investigate the behavior and function of interstitial stream, combined with new methodologies propose the demand in new agent to visualize the path itself. A macromolecule gadolinium-based agent PAA-Gd was introduced to outline the path while mass transportation was driven in Balb/c via interstitial stream and histology study was combined to perform in microscopic view as tracer. The novel agent can display its high efficiency to visualize the stream in radiology and pathology study as a versatile enhancer.

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