Interstitium space and interstitial stream compartmentalize organs distributed in different regions and compose human body among parenchymal tissues. The increase in interests to investigate the behavior and function of interstitial stream, combined with new methodologies propose the demand in new agent to visualize the path itself. A macromolecule gadolinium-based agent PAA-Gd was introduced to outline the path while mass transportation was driven in Balb/c via interstitial stream and histology study was combined to perform in microscopic view as tracer. The novel agent can display its high efficiency to visualize the stream in radiology and pathology study as a versatile enhancer.
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