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Abstract #1198

Assessment of Gd concentration estimated in DCE-MRI with multiple flip angles

Ayesha Bharadwaj Das1, James Andrew Tranos2, Jin Zhang1, Youssef Zaim Wadghiri2, and Gene Kim1
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Radiology, New York University School of Medicine, New York, NY, United States

The purpose of this study is to assess the accuracy of Gadolinium-based contrast agent (GBCA) concentration measured using the novel DCE-MRI method with two flip angles, without using the pre-contrast T1 measurement. The accuracy of the proposed method was assessed using the conventional approach with pre-contrast T1 measurement as well as the Gd concentration measurement using Inductively coupled plasma-mass spectrometry using the blood samples collected at the end of each scan. The results exhibited a strong correlation and agreement between the Gd concentration from the proposed two flip angle method and those from the conventional MRI method and ICP-MS analysis.

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