Our study shows that patients with a stable, spinal T2 lesion load do not benefit from the administration of GBCAs. In contrast to our previous cerebral study, there was no indication of spinal lesion re-activation. The T2 signal ratio has a high sensitivity and specificity to “predict” contrast enhancement of a given lesion and could be used as a predictive marker for “lesion activity”. In combination with previously published studies on the limited value of Gd-administration in cerebral MS follow-up investigations, we propose a “single-shot” MS protocol to combine cerebral and spinal MRI investigations in one standardized single MR protocol.
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