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Abstract #1201

Diagnostic value of Gd-contrast administration for spinal cord MRI in MS patients and T2 signal ratio as a predictive marker of lesion activity

Kianush Karimian-Jazi1, Ulf Neuberger1, Katharina Schregel1, Gianluca Brugnara1, Daniel Schwarz1, Laura Jäger2, Wolfgang Wick2, Martin Bendszus1, and Michael Oliver Breckwoldt1
1Neuroradiology, University Clinic of Heidelberg, Heidelberg, Germany, 2Neurology, University Clinic of Heidelberg, Heidelberg, Germany

Our study shows that patients with a stable, spinal T2 lesion load do not benefit from the administration of GBCAs. In contrast to our previous cerebral study, there was no indication of spinal lesion re-activation. The T2 signal ratio has a high sensitivity and specificity to “predict” contrast enhancement of a given lesion and could be used as a predictive marker for “lesion activity”. In combination with previously published studies on the limited value of Gd-administration in cerebral MS follow-up investigations, we propose a “single-shot” MS protocol to combine cerebral and spinal MRI investigations in one standardized single MR protocol.

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