Abstract #1202

Is MRI Contrast Stable in High-Energy Radiation of MR-Linac?

Travis Salzillo¹, Yongying Jiang², Yuri Mackeyev³, Clifton David Fuller¹, Caroline Chung¹, Seungtaek Choi¹, Neil Hughes¹, Yao Ding⁴, Jinzhong Yang⁴, Sastry Vedam⁵, Sunil Krishnan³, and Jihong Wang⁴

¹Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States, ²Institute for Applied Cancer Science, University of Texas MD Anderson Cancer Center, Houston, TX, United States, ³Radiation Oncology, Mayo Clinic, Jacksonville, FL, United States, ⁴Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁵Radiation Oncology, University of Maryland, Baltimore, MD, United States

Gadolinium-based MRI contrast agents are deemed safe to use in diagnostic exams. Their use would bring value to radiation oncology applications such as daily replanning on the MR-Linac. However, their stability and safe use in the presence of high-energy radiation remains unknown. We analyzed the chemical composition stability of two common MRI contrast agents that were irradiated to various doses using mass spectrometry. We found no detectable amounts of degradation compounds or conformational alterations as a result of irradiation. This is the first step towards demonstrating the safe use of gadolinium-based MRI contrast agents in radiation oncology applications.

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