Abstract #1204

Whole-Brain T1 and T2 Mapping in Mouse by 3D Magnetic Resonance Fingerprinting

Yuran Zhu¹, Yuning Gu¹, Kihwan Kim¹, Charlie Androjna², Chris A. Flask^1,3,4,5, Yong Chen^3,6, and Xin Yu^1,3,7

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States, ³Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, ⁴Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States, ⁵Cancer Imaging Program, Case Western Reserve University, Cleveland, OH, United States, ⁶Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁷Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

We present a 3D MR fingerprinting (MRF) sequence for simultaneous T₁ and T₂ mapping in mouse. Data acquisition and reconstruction covered a field of view (FOV) of 30 × 30 × 9 mm³ with a matrix size of 128 x 128 x 9, yielding a spatial resolution of 0.23 × 0.23 × 1 mm³. Retrospective undersampling analysis was performed on fully-sampled phantom and mouse data to examine the undersampling capacity of the proposed sequence, demonstrating that the method supports up to 16-fold in-plane undersampling with a 3-fold through-plane undersampling.

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