Abstract #1205

In vivo characterization of effect of microglia regeneration after high altitude exposure by quantitative MRI in mice

Alexandru V Korotcov^1,2, Caroline A Browne³, Andrew K Knutsen^1,2, Dara L Dickstein^2,4, Juan Wang⁴, Xiufen Xu^2,5, Kathleen Whiting^2,5, Shalini Jaiswal^1,2, Allison Nathanael¹, Daniel P Perl⁴, Zygmunt Galdzicki^2,5, and Bernard J Dardzinski^1,2

¹Radiology and Radiological Sciences, Uniformed Services University, Bethesda, MD, United States, ²Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, United States, ³Department of Pharmacology & Molecular Therapeutics, Uniformed Services University, Bethesda, MD, United States, ⁴Department of Pathology, Uniformed Services University, Bethesda, MD, United States, ⁵Department of Anatomy, Physiology and Genetics, Neuroscience Program, Uniformed Services University, Bethesda, MD, United States

Prolonged stays in high-altitude (HA) environments produce pro- and maladaptive physiological and pathological changes. Microglia depletion has been utilized in recovery from a spectrum of neurodegenerative diseases abnormalities. Advanced neuroimaging techniques demonstrate great promise to detect subtle changes in brain activity and morphology related to impairments induced by HA. In this work, we applied advanced MRI and modern behavioral tests to investigate neuropathological consequences of hypobaric hypoxia and the use of microglial regeneration as a novel approach to treat the maladaptive effect of HA.

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