Abstract #1215

Α-ATP suppression in 31P MR spectroscopy by homonuclear BIRD filter: An approach to quantify NAD+ and NADH at 3T in vivo

Julian Mevenkamp¹, Yvonne M.H. Bruls^1,2, Robin A. de Graaf³, Joachim E. Wildberger¹, Matthijs K.C. Hesselink², Lucas Lindeboom^1,2, and Vera B. Schrauwen-Hinderling^1,2

¹Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ²Department of Nutrition & Movement Sciences, Maastricht University, Maastricht, Netherlands, ³Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States

NAD⁺ and NADH play important roles in metabolism and metabolic health. Therefore, a non-invasive ³¹P MRS for the quantification of those metabolites on clinical 3T scanners was developed. This sequence suppresses α-ATP resonances based on homonuclear Bilinear Rotation Decoupling (BIRD). With reduced α-ATP intensity, neighbouring NAD⁺/H resonances appear as a separate peak. Results in eight young, lean and healthy volunteers show that the sequence succeeded in considerable α-ATP suppression. However, a clear separation of NADH and NAD⁺ resonances remains challenging due to remaining α-ATP signal.

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