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Abstract #1215

Α-ATP suppression in 31P MR spectroscopy by homonuclear BIRD filter: An approach to quantify NAD+ and NADH at 3T in vivo

Julian Mevenkamp1, Yvonne M.H. Bruls1,2, Robin A. de Graaf3, Joachim E. Wildberger1, Matthijs K.C. Hesselink2, Lucas Lindeboom1,2, and Vera B. Schrauwen-Hinderling1,2
1Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2Department of Nutrition & Movement Sciences, Maastricht University, Maastricht, Netherlands, 3Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States

NAD+ and NADH play important roles in metabolism and metabolic health. Therefore, a non-invasive 31P MRS for the quantification of those metabolites on clinical 3T scanners was developed. This sequence suppresses α-ATP resonances based on homonuclear Bilinear Rotation Decoupling (BIRD). With reduced α-ATP intensity, neighbouring NAD+/H resonances appear as a separate peak. Results in eight young, lean and healthy volunteers show that the sequence succeeded in considerable α-ATP suppression. However, a clear separation of NADH and NAD+ resonances remains challenging due to remaining α-ATP signal.

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