Abstract #1216

Validation of OxFlow Measurements of Whole-Brain CBF, OEF and CMRO2 by Simultaneous PET/MRI

Lucas Narciso^1,2, Tracy Ssali^1,2, Linshan Liu¹, Heather Biernaski¹, John Butler¹, Laura Morrison¹, Jennifer Hadway¹, Jeffrey Corsaut¹, Justin W. Hicks¹, Michael C. Langham³, Felix W. Wehrli³, Hidehiro Iida⁴, and Keith St Lawrence^1,2

¹Lawson Health Research Institute, London, ON, Canada, ²Department of Medical Biophysics, Western University, London, ON, Canada, ³University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, ⁴University of Turku and Turku PET Centre, Turku, Finland

OxFlow is a non-invasive MRI method for measuring whole-brain oxidative metabolism. This study presents its validation in an animal model by comparing to a PET-only method, as well as its sensitivity to alterations in cerebral metabolism. Strong correlations were observed between measurements from the MRI and PET techniques, with no significant differences. Furthermore, OxFlow proved sensitive to changes in metabolism induced by an increase in anesthetics.

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