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Abstract #1216

Validation of OxFlow Measurements of Whole-Brain CBF, OEF and CMRO2 by Simultaneous PET/MRI

Lucas Narciso1,2, Tracy Ssali1,2, Linshan Liu1, Heather Biernaski1, John Butler1, Laura Morrison1, Jennifer Hadway1, Jeffrey Corsaut1, Justin W. Hicks1, Michael C. Langham3, Felix W. Wehrli3, Hidehiro Iida4, and Keith St Lawrence1,2
1Lawson Health Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, 4University of Turku and Turku PET Centre, Turku, Finland

OxFlow is a non-invasive MRI method for measuring whole-brain oxidative metabolism. This study presents its validation in an animal model by comparing to a PET-only method, as well as its sensitivity to alterations in cerebral metabolism. Strong correlations were observed between measurements from the MRI and PET techniques, with no significant differences. Furthermore, OxFlow proved sensitive to changes in metabolism induced by an increase in anesthetics.

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