Abstract #1217

CNS Involvement in a Non-human Primate Model Infected with Aerosolized Ebola Virus

Byeong-Yeul Lee¹, Jeffrey M. Solomon², Marcelo Castro¹, Dong-Yun Kim³, Joseph Laux¹, Matthew G. Lackemeyer¹, Jordan K. Bohannon⁴, Anna N. Hanko⁵, Dima Hammoud^6,7, and Ji Hyun Lee¹

¹Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, United States, ²Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, United States, ³Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD, United States, ⁴National Biodefense Analysis and Countermeasures Center, Frederick, MD, United States, ⁵Microbiology, Boston University School of Medicine, Boston, MA, United States, ⁶Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, United States, ⁷Center for Infectious Disease Imaging, National Institutes of Health, Bethesda, MD, United States

We performed a quantitative neuroimaging study to determine central nervous system involvement following exposure with Ebola virus (EBOV) variant Makona via the aerosolized route in a rhesus monkey model. Using MR relaxometry, we found increases in T1 and R2* values in multiple brain regions. Notably, R2* changes corresponding to the deep cerebral venous system highly correlated with viral loads in CSF. These results provide in vivo evidence of brain involvement with EBOV and emphasize the potential of advanced imaging techniques to better understand the pathophysiology of organ involvement in various infectious diseases, including the brain.

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