Abstract #1219

Thalamic reticular nucleus injury as the cause of thalamocortical dysrhythmia in mild traumatic brain injury: a rodent model DTI study

Duen-Pang Kuo^1,2, Yi-Tien Li^1,3, Chen-Yin Ou¹, Yung-Chieh Chen^1,2, and Cheng-Yu Chen^1,2

¹Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan, ²Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, ³Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan

Thalamocortical dysrhythmia (TCD) has been implicated in the neuropsychiatric disorders in patients following mild traumatic brain injury (mTBI). We investigated the time-course diffusion tensor changes in the rodent brain up to 35 days using a controlled closed head injury model. Significant and persistent elevation of fractional anisotropy (FA) and reduced radial and mean diffusivities were found at the boundary of bilateral thalami where high shear stress was expected, suggesting that disinhibition of inhibitory circuits from the thalamic reticular nucleus (TRN) may play a role in TCD.

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