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Abstract #1222

Multiparametric functional magnetic resonance imaging for longitudinal evaluation of liver regeneration after 70% hepatectomy in a rat model

shuangshuang xie1, caixin qiu1, yajie sun1, jinxia zhu2, Robert Grimm3, and wen shen1
1Tianjin First Central Hospital, Tianjin, China, 2MR Collaboration, Siemens Healthcare Ltd., Beijing, China, 3MR Application Development, Siemens Healthcare GmbH, Erlangen, Germany

This study investigated the feasibility of multiparametric magnetic resonance imaging (MRI) (IVIM, DKI, BOLD) to evaluate the liver regeneration process after 70% hepatectomy in rats. MRI examination and pathologic samples were performed at multiple time-points. The results showed that D, D*, FP, MD, MK, and T2* can be used to monitor the microstructural changes after surgery, and D* and MK were significantly correlated with proliferative indexes of Ki - 67 and hepatocyte size. This suggests that multiparametric MRI can aid in noninvasive radiologic monitoring of liver regeneration and intrinsic microstructure evaluation

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