Abstract #1222

Multiparametric functional magnetic resonance imaging for longitudinal evaluation of liver regeneration after 70% hepatectomy in a rat model

shuangshuang xie¹, caixin qiu¹, yajie sun¹, jinxia zhu², Robert Grimm³, and wen shen¹

¹Tianjin First Central Hospital, Tianjin, China, ²MR Collaboration, Siemens Healthcare Ltd., Beijing, China, ³MR Application Development, Siemens Healthcare GmbH, Erlangen, Germany

This study investigated the feasibility of multiparametric magnetic resonance imaging (MRI) (IVIM, DKI, BOLD) to evaluate the liver regeneration process after 70% hepatectomy in rats. MRI examination and pathologic samples were performed at multiple time-points. The results showed that D, D*, FP, MD, MK, and T2* can be used to monitor the microstructural changes after surgery, and D* and MK were significantly correlated with proliferative indexes of Ki - 67 and hepatocyte size. This suggests that multiparametric MRI can aid in noninvasive radiologic monitoring of liver regeneration and intrinsic microstructure evaluation

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