Social interactions, like sleep, is the basic needs for humans and animals, its neural mechanism is not fully understood. Domestic dog has similar emotional and social processing with humans, it would be a promising animal model for social interaction. In this study, 3 beagles were social deprived (SD) 4-week, and performed resting-state fMRI and diffusion MRI. The functional connectivity and diffusion metrics were compared between SD and wild type dogs. We found the functional connectivity strengthened within prefrontal cortex and weakened between prefrontal cortex with visual and auditory cortex in SD. Demyelination observed in frontal, temporal, and insula regions.
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