Abstract #1225

A pilot study of socially deprivated brain alterations using fMRI and dMRI in domestic dogs

Xueru Liu^1,2, Huilin Hong³, Zhentao Zuo^1,2,4, Hui Zhao³, Rui Tian³, Yongqing Zhang^2,3,4, and Yan Zhuo^1,2,4

¹State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, BeiJing, China, ²University of Chinese Academy of Sciences, Beijing, China, ³State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China, ⁴CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China

Social interactions, like sleep, is the basic needs for humans and animals, its neural mechanism is not fully understood. Domestic dog has similar emotional and social processing with humans, it would be a promising animal model for social interaction. In this study, 3 beagles were social deprived (SD) 4-week, and performed resting-state fMRI and diffusion MRI. The functional connectivity and diffusion metrics were compared between SD and wild type dogs. We found the functional connectivity strengthened within prefrontal cortex and weakened between prefrontal cortex with visual and auditory cortex in SD. Demyelination observed in frontal, temporal, and insula regions.

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