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Abstract #1224

Characterization of cardiac function in early-stage pulmonary arterial hypertension in asymptomatic BMPR2 mutant rats by MRI and 31P MRS

Dounia El Hamrani1,2, Julie Magat1,2, Jérôme Naulin1,2, Frédéric Perros3, Marilyne Campagnac2, David Benoist1,2, Christelle Guibert2, and Bruno Quesson1,2
1IHU LIRYC, Bordeaux, France, 2INSERM U1045, CRCTB, Bordeaux, France, 3INSERM UMR_S 999, Université Paris–Saclay, Le Kremlin Bicêtre, France

The transgenic rat line studied has a monoallelic mutation of Bmpr2 which is a model of heritable pulmonary arterial hypertension. The purpose of this study is to evaluate cardiac differences between wild type and asymptomatic mutated rats by cardiac MRI and 31P MRS. Transgenic rats showed a decrease in end-diastolic and end-systolic volumes of ventricles leading to a reduced stroke volume. These results indicate a significant decrease in cardiac output but without ventricular hypertrophy (constant wall thickness) and no significant variation of ejection fraction. The cardiac energy balance (phosphocreatine/ATPβ) remained unaltered in Bmpr2 rats at rest and post-injection of dobutamine.

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