Porphyrinic photosensitizers (PSs) like chlorin e4 (Ce4) are applied with polymer-based carriers for photodynamic therapy of cancer. However, the impact of PSs and their carriers on the metabolic state of cells in the dark-interval before light treatment are not clear. Here, HR-MAS NMR metabolomics was applied to cancer cells treated with Ce4 alone or combined with polyvinylpyrrolidone (PVP) or block-copolymer micelles (BCMs). A Ce4-concentration dependent metabolic response was observed that was clearly attenuated by BCMs and more pronounced by PVP indicating the beneficial role of the carriers. Direct interaction of Ce4 with glycero-phosphocholine was observed suggesting intracellular membrane localization.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords