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Abstract #1228

Absolute quantification of cardiac 31P metabolites using surface loop and dipole array coils at 7T

Jabrane Karkouri1, Stanislav Frištyk2, Lucian AB Purvis3, Christopher T. Rodgers*1, and Ladislav Valkovic*3
1Wolfson Brain Imaging Center, University of Cambridge, Cambridge, United Kingdom, 2Department of Electromagnetic and Biomedical Engineering, University of Žilina, Zilina, Slovakia, 3Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom

Phosphorus magnetic resonance spectroscopy (31P-MRS) delivers unique information to aid our understanding of cardiac metabolism. To quantify “absolute” concentrations of phosphorus metabolites (i.e. in recognised units such as mmol / kg wet weight), sensitivity calibration and transmit field correction are required. Ultrahigh field (>7 T) magnets and the use of multichannel RF coils make this even more challenging. In this study, we investigate the feasibility of absolute concentration of phosphorus metabolites in the human heart at 7T, compare our findings to literature values and evaluate reproducibility with different coils and different MR systems.

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