Abstract #1229

Deuterium MRI brain mapping of absence seizure medication: ethosuximide illustration

Andrey N. Pravdivtsev¹, Arne Brahms², Jens Gröbner³, Rosa Rojas⁴, Eva Peschke¹, Anna-Sophia Buschhoff⁴, Frowin Ellermann¹, Rainer Herges², Jan-Bernd Hövener¹, and Peer Wulff⁴

¹Section Biomedical Imaging, MOIN CC, Kiel University, Kiel, Germany, ²Otto Diels Institute for Organic Chemistry, Kiel University, Kiel, Germany, ³Fachhochschule Südwestfalen, Fachbereich Elektrotechnik und Informationstechnik, Lüdenscheid, Germany, ⁴Institute of Physiology, Kiel University, Kiel, Germany

The mechanisms of action of many common antiepileptics are currently not fully understood. These drugs have a narrow therapeutic window with some severe side effects. Here, we are setting up a pipeline to study the distribution of CNS-targeting drugs non-invasively with MRI, using deuterium (²H) labelling and deuterium magnetic resonance spectroscopy.

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