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Abstract #1229

Deuterium MRI brain mapping of absence seizure medication: ethosuximide illustration

Andrey N. Pravdivtsev1, Arne Brahms2, Jens Gröbner3, Rosa Rojas4, Eva Peschke1, Anna-Sophia Buschhoff4, Frowin Ellermann1, Rainer Herges2, Jan-Bernd Hövener1, and Peer Wulff4
1Section Biomedical Imaging, MOIN CC, Kiel University, Kiel, Germany, 2Otto Diels Institute for Organic Chemistry, Kiel University, Kiel, Germany, 3Fachhochschule Südwestfalen, Fachbereich Elektrotechnik und Informationstechnik, Lüdenscheid, Germany, 4Institute of Physiology, Kiel University, Kiel, Germany

The mechanisms of action of many common antiepileptics are currently not fully understood. These drugs have a narrow therapeutic window with some severe side effects. Here, we are setting up a pipeline to study the distribution of CNS-targeting drugs non-invasively with MRI, using deuterium (2H) labelling and deuterium magnetic resonance spectroscopy.

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