Abstract #1232

Quantitative myelin-sensitive MRIs exhibit differential sensitivity to multiple sclerosis pathology in distinct brain lesions and regions

Reza Rahmanzadeh^1,2,3, Po-Jui Lu^1,2,3, Muhamed Barakovic^1,2,3, Matthias Weigel^1,2,3, Laura Gaetano⁴, Riccardo Galbusera^1,2,3, Thanh D. Nguyen⁵, Francesco La Rosa ^6,7, Daniel S. Reich⁸, Pascal Sati^8,9, Yi Wang⁵, Meritxell Bach Cuadra^6,7, Ernst-Wilhelm Radue^1,2, Jens Kuhle^1,3, Ludwig Kappos^1,3, Stefano Magon¹⁰, and Cristina Granziera^1,2,3

¹Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, ²Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, ³Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB) Basel, University Hospital Basel and University of Basel, Basel, Switzerland, ⁴Hoffmann-La Roche Ltd., Basel, Switzerland, ⁵Department of Radiology, Weill Cornell Medical College, New York, NY, United States, ⁶Signal Processing Laboratory (LTS5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Laussane, Switzerland, ⁷Radiology Department, Center for Biomedical Imaging (CIBM), Lausanne University and University Hospital, Laussane, Switzerland, ⁸Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, NIH, 10 Center Drive MSC 1400, Building 10 Room 5C103, Bethesda, MD, United States, ⁹Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ¹⁰Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland

The differential sensitivity of myelin-sensitive advanced MRIs (aMRIs) to the pathology in various brain lesions and regions in multiple sclerosis (MS) is currently debated. This study aimed to address this issue using myelin water fraction maps (MWF), quantitative susceptibility mapping (QSM) and T1 relaxometry (qT1). Our results show that (i) qT1 is the most sensitive in differentiating white matter and cortical MS lesions from normal-appearing tissue (ii) QSM is best differentiating lesions with various extent of damage (lesions with vs without paramagnetic rim & periventricular vs juxta-cortical lesions) and (iii) MWF outperforms the other aMRI methods in identifying occult normal appearing pathology.

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