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Abstract #1233

Three-dimensional whole-brain simultaneous quantitative mapping of T1, T2, T2*, and susceptibility with MR Multitasking

Tianle Cao1,2, Sen Ma1, Nan Wang1, Sara Gharabaghi3, Yibin Xie1, Zhaoyang Fan1,4,5, Elliot Hogg6, E. Mark Haacke 3,7,8, Michele Tagliati6, Anthony G. Christodoulou1,2, and Debiao Li1,2
1Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Magnetic Resonance Innovations, Inc., Bingham Farms, MI, United States, 4Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 5Department of Radiology, University of Southern California, Los Angeles, CA, United States, 6Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA, United States, 7Department of Radiology, Wayne State University School of Medicine, Detroit, MI, United States, 8The MRI Institute for Biomedical Research, Bingham Farms, MI, United States

A new approach for simultaneous quantitative mapping of T1, T2, T2*, and susceptibility was developed. This technique employs hybrid T2 preparation/inversion pulse modules followed by fully flow-compensated multi-echo FLASH readouts. Our method reconstructs images with different T2 preparation times, echo times, and inversion times in the MR Multitasking framework and use them for parameter quantification. Results of both visual comparison and statistical analysis showed that our proposed method agreed well with reference methods while being more time efficient.

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