Quantitative T1 and T2 mapping has shown promising results in the quantification of liver fibrosis and inflammation, whereas proton density fat fraction mapping has been used to quantify the hepatic lipid content in fatty liver diseases. Conventionally multiple sequential 2D breath-held scans are performed to acquire sequential 2D T1, T2 and fat fraction maps. However, this approach suffers from limited spatial resolution and coverage and potential misregistration errors. In this work, we sought to develop a free-breathing non-rigid motion corrected 3D sequence for simultaneous and co-registered acquisition of joint liver T1, T2 and fat fraction maps for quantitative tissue characterization
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