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Abstract #1236

Generation of co-registered multi-contrast MR images for carotid atherosclerosis evaluation based on a single SIMPLE sequence

Jiaqi Dou1, Yajie Wang1, Huiyu Qiao1, Zhensen Chen1, Yuze Li1, Haikun Qi2, Jie Sun3, Dongxiang Xu3, Xihai Zhao1, and Huijun Chen1
1Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, 2School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 3Department of Radiology, University of Washington, Seattle, WA, United States

Carotid atherosclerosis is a leading cause of ischemic stroke worldwide. Multi-contrast magnetic resonance imaging (MRI) is an ideal non-invasive technique to assess carotid plaque. However, its clinical application is limited by long scan time and non-rigid registration between different contrasts. In this study, we generated a set of co-registered T1w, T2w, PDw images, and MR angiogram (MRA) in one scan based on the SIMPLE (SImultaneous T1 and T2 Mapping of carotid PLaquE) sequence. Preliminary experiments on patients validated the feasibility of the generated multi-contrast images for carotid plaque assessment and comparable performance with conventional sequences.

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