Abstract #1236

Generation of co-registered multi-contrast MR images for carotid atherosclerosis evaluation based on a single SIMPLE sequence

Jiaqi Dou¹, Yajie Wang¹, Huiyu Qiao¹, Zhensen Chen¹, Yuze Li¹, Haikun Qi², Jie Sun³, Dongxiang Xu³, Xihai Zhao¹, and Huijun Chen¹

¹Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, ²School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³Department of Radiology, University of Washington, Seattle, WA, United States

Carotid atherosclerosis is a leading cause of ischemic stroke worldwide. Multi-contrast magnetic resonance imaging (MRI) is an ideal non-invasive technique to assess carotid plaque. However, its clinical application is limited by long scan time and non-rigid registration between different contrasts. In this study, we generated a set of co-registered T1w, T2w, PDw images, and MR angiogram (MRA) in one scan based on the SIMPLE (SImultaneous T1 and T2 Mapping of carotid PLaquE) sequence. Preliminary experiments on patients validated the feasibility of the generated multi-contrast images for carotid plaque assessment and comparable performance with conventional sequences.

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