Malignant brain tumor patients treated with radiation are at risk of developing subsequent treatment effects, including radiation necrosis (RN), which cannot be differentiated from recurrent tumor. We have developed mouse models of RN and of admixed tumor growing in previously irradiated brain (“mixed lesion”) that recapitulate the major histologic characteristics of human RN and recurrent glioma, respectively. These models provide a platform for the development of imaging biomarkers capable of differentiating RN vs. tumor. We demonstrate a multiparametric, clinically translatable 1H MRI pipeline (R1, R1-post-contrast, R2, ADC, MTR, and DCEAUC) that shows significant promise for differentiating RN vs. recurrent tumor.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords