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Abstract #1238

Changes of native T1, T1ρ, and T2 values during liver fibrosis in rats at 11.7T MRI

Yimei Lu1, Qianfeng Wang2, and Dengbin Wang1
1Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, shanghai, China, 2Fudan University, Institute of Science and Technology for Brain-Inspired Intelligence, shanghai, China

The relaxation times (including T1, T2, and T1ρ) are tissue-specific parameters , and depend on the physical, chemical and biological characteristics of the tissue. In liver fibrosis, the deposition of macromolecules (such as collagen fibers, proteoglycans, etc.) in the extracellular matrix may affect the movement of free protons, resulting in tissue relaxation times change. Many studies have shown that native T1 and T2 values are related to the degree of liver fibrosis. We investigate the influence of different pathological changes on T1 mapping, T1ρ, and T2 mapping in two vivo animal models of liver fibrosis, with a focus on liver fibrosis.

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