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Abstract #1258

Theoretical evaluation of the feasibility to detect label-exchange by proton MRS at 7T in human brain after administration of deuterated glucose.

Simone Poli1, Lia Bally2, Roland Wiest3, and Roland Kreis1
1Department of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, 2Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital and University of Bern, Bern, CH, Bern, Switzerland, 3Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, Bern, CH, Bern, Switzerland

This study aims to analyze the feasibility of indirect detection by 1H MRS of cerebral metabolism following intake of deuterated glucose in humans on a clinical 7T system. Brain spectra before and after [6,6’-2H2]-glucose administration were simulated with realistic SNR and linewidth to evaluate the best achievable precision in quantifying specific deuterated and non-deuterated metabolites. We expect labeling of glutamate, lactate and glutamine to be observable from single spectra of large VOIs, but also in MRSI at resolutions of 2-5 cm3. The simulations were corroborated with phantom data but eventual feasibility will remain to be confirmed in vivo.

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