Abstract #1258

Theoretical evaluation of the feasibility to detect label-exchange by proton MRS at 7T in human brain after administration of deuterated glucose.

Simone Poli¹, Lia Bally², Roland Wiest³, and Roland Kreis¹

¹Department of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, ²Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital and University of Bern, Bern, CH, Bern, Switzerland, ³Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, Bern, CH, Bern, Switzerland

This study aims to analyze the feasibility of indirect detection by ¹H MRS of cerebral metabolism following intake of deuterated glucose in humans on a clinical 7T system. Brain spectra before and after [6,6’-²H₂]-glucose administration were simulated with realistic SNR and linewidth to evaluate the best achievable precision in quantifying specific deuterated and non-deuterated metabolites. We expect labeling of glutamate, lactate and glutamine to be observable from single spectra of large VOIs, but also in MRSI at resolutions of 2-5 cm³. The simulations were corroborated with phantom data but eventual feasibility will remain to be confirmed in vivo.

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